Any floated floor, other than one that's floated over an even layer of compressible material (like rockwool) will exert POINT loading on the under-floor; before you can decide this question, you MUST know what is already there. PRECISELY what, and precisely WHERE. Without this knowledge, you're asking for death.
For a wood framed floor to support a floated floor, the floating pucks MUST be centered over the existing joists; they MUST be spaced close enough NOT to put all the weight on one section of existing joist; and the existing floor MUST be able to support the extra weight, in the case of a fully floated room, of ALL the new building materials AND the occupancy AND the equipment, or someone may die.
If you go with lighter materials in order to stay within the support capabilities of the existing floor, then to compensate for the higher m-a-m frequency this will cause, you can use deeper floated joists; this will widen the air gap (completely filled with rockwool, or boomy; your choice) - a wider air gap, with no other changes, will lower m-a-m frequency (a GOOD thing) - ideally, especially for drums and bass, the m-a-m frequency should be an octave or more below audible; IOW, 10 hZ or less. This isn't easy without using heavy mass, but can be compensated for somewhat by thicker joists.
BTW, unless you're planning on moving out in 10 years or less, I'd go with EPDM instead of Neoprene - more expensive, but more like 25 year life expectancy instead of 10 -
Some background -
http://www.earsc.com/HOME/engineering/T ... asp?SID=61
note the yellow and gray graphic about 40% of the way down the page - this is why non-calculated floating floors can be such a crapshoot... Steve